Sone-431 [new] Jun 2026

If you're looking for a general outline or structure for a paper, I can provide a basic template. Here is a general outline:

| Step | Transformation | Reagents / Conditions | Yield (lab) | Yield (pilot) | |------|----------------|-----------------------|-------------|---------------| | 1 | (4‑fluorobenzaldehyde + 2‑amino‑5‑fluorobenzenethiol) | MeOH, 0 °C → rt, 2 h; catalytic AcOH | 88 % | 84 % | | 2 | Cyclization to 1,3‑benzothiazine | POCl₃, pyridine, 80 °C, 3 h | 71 % | 68 % | | 3 | Oxidation to 2‑one | m‑CPBA, CH₂Cl₂, 0 °C → rt, 4 h | 78 % | 73 % | | 4 | Final fluorination (introducing the second F) | NFSI, DMF, 60 °C, 6 h | 69 % | 65 % | | Overall | — | — | ≈ 30 % (lab) | ≈ 45 % (pilot, with optimized work‑up) | sone-431

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