This is a comprehensive guide to Plague Inc: Evolved (and the mobile version) covering all official scenarios, plague types, and strategies for dominating the world on Mega Brutal difficulty.
Plague Inc: The Complete DLC & Scenario Guide Table of Contents
Universal Mechanics (The fundamentals for all modes) Standard Plague Types (Bacteria to Bio-Weapon) Specialized Plague Types (Neurax, Necroa, Simian Flu) Major DLC Scenarios (Shadow Plague, Santa’s Little Helper, etc.) Multiplayer Strategies Achievement Hunting Tips
1. Universal Mechanics: The Golden Rules Before diving into specific plagues, you must master the core "Meta" of the game. plague inc all dlc
Genetic Code Reshuffling:
DNA Gene: Metabolic Jump (Essential for DNA income). Cytochrome Surge is great for speed runs. Travel Gene: Native Biome (Helps infect your starting country faster) or Teracyte (Better ship transmission). Evolution Gene: Sympto-Stasis (Symptoms cost less DNA—crucial for high-cost plagues). Darwinist is good for random mutations. Environment Gene: Extremophile (Bonus in all environments) or Drought Tolerance . Mutation Gene: Genetic Mimic (Harder to cure) or Creationist (Slows cure research speed).
Start Locations:
India: The meta start. High population, dense, airport/seaport access, hot climate. Saudi Arabia: Excellent for airport spreading and rich country infection. China: Good for population density, but slows cure research slightly less effectively than others. Greenland Start: Only start here if you have Native Biome gene. It is isolated but has a port.
The "Kill Switch" Strategy:
Do not evolve killing symptoms early. Devolve any lethal mutations immediately. Infect everyone silently. Once the world is 100% infected (or close to it), evolve lethal symptoms simultaneously (Total Organ Failure, Hemorrhagic Shock, Necrosis). This is a comprehensive guide to Plague Inc:
2. Standard Plague Types Bacteria
Ability: Bacterial Resilience (Survives well in all climates). Strategy: The tutorial plague.
