In a massive late-season revelation, Michael and Lincoln’s mother is revealed to be alive and working as a high-level operative for The Company with her own agenda for Scylla. Recurring Characters & Antagonists

Is it the best season? Many fans argue no—the Scylla plot gets convoluted. But the ? Absolutely top-tier. This group of actors committed to the chaos, delivering a gritty, globe-trotting finale (before the eventual Final Break movie).

Love him or hate him, Rapaport brings chaotic energy. Self is the Homeland Security agent who assembles the team to steal Scylla—only to reveal he’s actually a traitor. His whiny betrayal and eventual fate (hello, locked-in syndrome) make him a memorable wildcard.

What makes Prison Break Season 4 unique is that it finally turns the antagonists into protagonists. Watching Mahone, Bellick, and even T-Bag (temporarily) fight on the same side as Michael and Lincoln is the payoff of 80+ episodes of character building.

When Prison Break returned for its fourth season in 2008, the game had completely changed. Gone were the tattoos and the blueprints of Fox River. Season 4 was all about revenge, high-tech heists, and taking down “The Company” for good.

The Company’s "Terminator-style" hitman. He is the season’s most cold-blooded antagonist, tasked with eliminating anyone tracking Scylla.