If the file system is corrupted, changing permissions won't help. You need to repair the logical structure of the drive.
Navigate to: HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer e is not accessible access is denied
If the issue is permission-based, you must manually grant your user account access. If the file system is corrupted, changing permissions
Fix “E:\ is not accessible. Access is denied” on Windows If the file system is corrupted